PhD position in Multimodal Biophotonics Imaging of Biomarkers for Bladder Cancer: Development of a Combined OCT/OCM and MPM Endoscop

DTU Fotonik
Friday 24 Feb 17

Apply for this job

Apply no later than 31 March 2017
Apply for the job at DTU Fotonik by completing the following form.

Apply online

The Department of Photonics Engineering at the Technical University of Denmark has an open PhD position (early-stage researcher) in the H2020 MSCA ITN project “Multimodal, Functional Bio-Photonic Imaging (FBI)”. FBI aims to foster the next generation of researchers who will enable Europe to take a leading role in the multidisciplinary area of functional biophotonic imaging applications involving components and complete systems for diagnostics of cancer.

Description of PhD project
The optical imaging family is a diverse, versatile field to assess cellular and subcellular information in biological material. Combining different imaging modalities into a multimodal platform enables fast diagnosis of lesions in a clinical environment. The aim of this PhD project is to combine two such modalities, namely Two-Photon Excited Fluorescence Microscopy (TPEFM) and Optical Coherence Microscopy (OCM), into a common platform and show the hypothesized superior sensitivity and specificity when grading tumour cells using cancerous lesions in bladder tissue histologies.

You work closely together with clinicians to gain expertise on biopsy handling and imaging using both TPEFM and OCM. Biomarkers for grading bladder cancer provided by the TPEFM imaging modality, such as NADH and FAD, are evaluated and optimized for, by using different excitation wavelengths and different detection setups (intensity, spectrum, time). The OCM imaging system is optimized for the respective biomarkers in bladder cancer in collaboration with the Medizinische Universität Wien. Automated analysis routines for images from both the TPEFM and OCM system are developed with input from Philips. The two optimized systems are combined into one microscopy imaging platform, capable of acquiring images from both modalities in parallel. The automated analysis routines are also combined to show an increase in sensitivity and specificity regarding grading. Finally, in order to be clinically applicable, the light delivery and collection system is compacted such that it fits into a fibre-based endoscope.

During the project, you will collaborate closely with the other FBI consortium groups and with Gentofte Hospital, including extended research stays at the Medizinische Universität Wien, Austria, and at Philips, The Netherlands.

Qualifications
The candidate should have a master's degree in applied physics, biophotonics, photonics engineering or a similar degree with an academic level equivalent to the master's degree in engineering. Solid experience in TPEFM and OCT/OCM is preferred, and knowledge of fibre optics is considered advantageous. We expect the candidate to have good laboratory skills in the above areas. Good communication skills in written and spoken English are a must. Starting date is spring 2017 or earlier.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.   

Assessment
The assessment of the applicants will be made by Senior Researcher Peter E. Andersen, Postdoc Dominik Marti, Researcher Anders Kragh Hansen.   

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contributes to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.  

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

The primary workplace is DTU Fotonik, DTU Risø Campus, Roskilde, Denmark. The PhD will take part in a secondment to at least one other project partner for up to 30% of their appointment period. Mobility Allowances and Family Allowances (dependant on family circumstances) are payable to the ESR.  

Further information
Further information may be obtained from Senior Researcher Peter E. Andersen, Diode Lasers and LED Systems group, tel. +45 46774555 and email peta@fotonik.dtu.dk.   

You can read more about the Department of Photonics Engineering on www.fotonik.dtu.dk/english.   

Application
Please submit your online application no later than 31 March 2017. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include: 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.

Due to the mobility requirement of the European Commission for ITN projects, we can only accept PhD candidates that have not been working/living in Denmark for more than 12 months within the last 3 years.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.   

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.