PhD position: Two-photon Selective Plane Illumination Microscopy through Fibres

DTU Fotonik
Tuesday 13 Jun 17

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The Department of Photonics Engineering at the Technical University of Denmark has an open PhD position in the project “Two-photon Selective Plane Illumination Microscopy through Fibres (T-SPIF)”. The subject of the project is at the cutting edge of science and will involve collaboration with international experts and industry. We expect this work to result in publications in high ranking journals.

Description of PhD project
For many human diseases, early diagnosis is crucial for a positive therapy outcome, but would require techniques for fast microscopic imaging of tissues inside the body at a resolution level of individual cells. One promising idea on how to accomplish this is to combine three existing techniques: (1) Two-photon microscopy provides a high imaging resolution at large depths, allowing individual cells to be imaged, (2) Selective Plane Illumination allows fast 3D image formation because an entire plane of tissue can be imaged at a time, and (3) delivering the light through fibres enables integration into endoscopes, which in turn enables access to many hollow organs inside the human body.

Such a combination of techniques could be ground-breaking in point-of-care diagnostics. This ambitious PhD project, “Two-photon Selective Plane Illumination Microscopy through Fibres (T-SPIF)”, funded by Det Frie Forskningsråd | Teknologi og Produktion (DFF FTP), aims to accomplish this challenging combination of techniques.  

In this project, you will explore, theoretically and experimentally, methods of shaping both spatial and temporal beam and phase profiles of ultrafast pulses of laser light using a spatial light modulator (SLM), to generate a light sheet at the distal end of either a multimode or multicore fibre. The theoretical modelling will include the effects of fibre propagation, including dispersion, phase shift and the influence of fibre bending. The project aims at imaging tissue samples using the developed system towards the end of the project.

During the project, you will collaborate with the fibre manufacturer OFS, and the project includes an extended research stay at University of St. Andrews in Scotland in the group of Prof. Kishan Dholakia, one of the world leaders in laser beam shaping and selective plane illumination microscopy.   

Qualifications
The candidate should have a master's degree in photonics, physics, telecommunication or similar. Solid experimental and theoretical skills in optics, lasers and photonics are expected. Good communication skills in written and spoken English are a must. Preferred starting month is October or November 2017.   

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.    

Assessment
The assessment of the applicants will be made by Researcher Anders Kragh Hansen, Postdoc Dominik Marti and Senior Researcher Peter E. Andersen.

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

The primary workplace is DTU Fotonik, DTU Risø Campus, Roskilde, Denmark. At some point during the project, the PhD will stay externally at University of St. Andrews in Scotland for up to 6 months.

Further information
Further information may be obtained from Researcher Anders Kragh Hansen, Diode Lasers and LED Systems group, tel. +45 46774586 and email ankrh@fotonik.dtu.dk

You can read more about the Department of Photonics Engineering on www.fotonik.dtu.dk/english.    

Application
Please submit your online application no later than 23 July 2017. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include: 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma (an official translation into English)
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Candidates may apply prior to ob­tai­ning their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Fotonik has 210 employees with competences in optics and is one of the largest centers in the world based solely on research in photonics. Research is performed within optical sensors, lasers, LEDs, photovoltaics, ultra-high speed optical transmission systems, bio-photonics, nano-optics and quantum photonics.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.